Figure 3.

The blockade of P/Q-type Ca²⁺ channels by ω-agatoxin suppresses both release components in WT and SynII(−) genotypes. A, The blockade of P/Q-type Ca²⁺ channels by ω-agatoxin IVA (10 nm) significantly reduces basal inhibitory transmission in both genotypes. B, Representative traces illustrate a uniform reduction of the postsynaptic current produced by the ω-agatoxin IVA treatment in both genotypes. C, The ω-agatoxin IVA treatment does not affect the frequency of asynchronous peaks in either of the genotypes. D, The effect of ω-agatoxin IVA on the charge transfer during the tetanus is similar at WT and SynII(−) slices. E, The effect of ω-agatoxin IVA on the charge transfer after the tetanus is similar at WT and SynII(−) slices. F, The ω-agatoxin IVA treatment does not affect the After/During charge ratio in either of the lines. Data collected from 13 slices for each genotype. *p < 0.05, **p < 0.01.