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. 2017 Feb 15;37(7):1757–1771. doi: 10.1523/JNEUROSCI.0844-16.2016

Figure 8.

Figure 8.

SynII deletion suppresses the synchronous release component and enhances the asynchronous release component at FS (PV) interneurons. A, Representative traces illustrate a mild selective increase in the after tetanus current in the SynII(−) line. B, The frequency of asynchronous IPSCs is significantly (p < 0.05) increased at SynII(−) neurons, whereas the sIPSC frequency is not affected. Left traces, Examples of asynchronous and spontaneous IPSCs. C, The charge transfer after the tetanus is selectively increased at SynII(−) neurons. This is evident from the right shift in the cumulative distribution representing the after tetanus charge (p < 0.05, Kolomogorov–Smirnov test) and a significant increase in the After/During charge ratio at SynII(−) neurons (p < 0.05). D, The synchronous release component at WT and SynII(−) KO interneurons computed using deconvolution. E, The asynchronous release component computed using deconvolution. Right plot, Data normalized by the first response in a tetanus. F, The cumulative asynchronous release component is significantly increased at SynII neurons (p < 0.05). Dotted lines indicate the confidence interval. G, The cumulative synchronous release component is significantly decreased at SynII neurons (p < 0.05). Dotted lines indicate the confidence interval. H, The ratio between the total asynchronous and synchronous release components is significantly increased at SynII(−) neurons (p < 0.05). Data collected from six pairs for each genotype. *p < 0.05.