Figure 9.

SynII deletion desynchronizes basal transmission at regular spiking (CCK) interneurons and synchronizes transmission at FS (PV) interneurons. A, Representative traces illustrate higher IPSC amplitudes and faster kinetics at RS SynII(−) neurons. B, The average IPSC traces normalized by the peak amplitudes demonstrate a narrower time course at the currents recorded from FS SynII(−) pairs. C, The normalized cumulative charge plot shows a significantly faster IPSC kinetics at the SynII(−) line (p < 0.05, Kolomogorov–Smirnov test). D–F, At FS interneurons, SynII deletion produces a slower IPSC kinetics. G, SynII deletion increases the IPSC amplitude at RS interneurons and decreases the IPSC amplitude at FS interneurons (p < 0.05, one-way ANOVA followed by the Tukey's test). H, SynII(−) deletion does not affect the IPSC charge at either of the interneuron subtypes, suggesting that the release magnitude is not affected. I, The ratio between the IPSC charge and amplitude, as a measure of IPSC kinetics. SynII(−) deletion significantly reduces the ratio at RS interneurons and significantly increases the ratio at FS interneurons (p < 0.05, one-way ANOVA followed by the Tukey's test), suggesting that SynII regulates the release kinetics at FS and RS interneurons in opposite ways. *p < 0.05.