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. 2017 Feb 15;37(7):1888–1899. doi: 10.1523/JNEUROSCI.2712-16.2017

Figure 6.

Figure 6.

Oxidative phosphorylation plays a privileged role in recovery from intense presynaptic activity. A, Schematic and representative data showing autaptic EPSCs evoked by action potentials in normal glucose solution before (left) and after (right) vesicle depletion with strong, sustained depolarization with 90 mm K+ for 30 s. Stimulus action currents in this figure and subsequent figures are blanked for clarity. B, C, Representative recovery traces from 2DG (B) and oligo-alone (C) treatments showing poor recovery from vesicle depletion in the oligo alone condition. D, E, Summary of recovery of action-potential-evoked EPSCs after the depletion protocol for 2DG compared with glucose control (D, p > 0.05, two-way ANOVA) and glucose saline in the presence (+oligo) or absence (-oligo) of 1 μm oligomycin (E, p < 0.05 two-way ANOVA). F, G, Summary of axosomatic sodium currents after the depletion protocol for 2DG compared with glucose control (F, p > 0.05, two-way ANOVA) and glucose saline in the presence or absence of oligomycin (G, p > 0.05, two-way ANOVA). Data are represented as mean ± SEM. *p ≤ 0.05; n.s, nonsignificant.