Skip to main content
. 2017 Feb 15;37(7):1950–1964. doi: 10.1523/JNEUROSCI.3196-16.2017

Figure 3.

Figure 3.

Facilitation, CS bursting, and LTP induction are reduced in dorsal hippocampal slices from Syt7−/− mutant mice. A, Paired-pulse facilitation is significantly reduced in dorsal hippocampal slices from Syt7−/− mice. **p < 0.001 (two-way ANOVA with Student-Newman-Keuls post hoc multiple-comparisons test). p = 3.7 × 10−24, F(1,36) = 609.2 (n = 18 slices from 6 wild-type and n = 15 slices from 5 Syt7−/− mutant mice). B, C, fEPSP slopes (B) and number of population spikes (C) elicited during TPS in slices from wild-type (n = 18 slices from 6 mice) and Syt7−/− mutants (n = 15 slices from 5 mice). Shading represents SEM. The latency to first burst (first stimulation pulse to elicit 2 or more population spikes) was 28 ± 3.1 pulses in slices from wild-type mice and 55 ± 6.7 pluses in slices from Syt7−/− mice (p = 4.1 × 10−4, Student's t test: t(9) = 5.445). D, Examples of fEPSPs elicited during TPS in slices from wild-type (top) and Syt7−/− mutant mice. Calibration: 2 mV, 5 ms. E, TPS stimulation-induced LTP is reduced in Syt7−/− mutant mice (p = 0.014, Student's t test: t(9) = 3.045). At 45 min after TPS (delivered at time = 0), fEPSPs were potentiated to 148 ± 4% of baseline in slices from wild-type littermates (p = 8.38 × 10−7, paired t test: t(17) = 7.521) and were 121 ± 8% of baseline in slices from Syt7−/− mutants (p = 1.86 × 10−3, paired t test: t(14) = 3.824). Results from the same experiments shown in B, C.