Table 1.

Mean live Ixodes holocyclus counts and efficacy relative to placebo at 8, 12, 24 and 48 h after treatment for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0

Treatment		Tick counting time points post-treatment
		8 h	12 h	24 h	48 h
Placebo	Range	21–28	20–28	19–28	19–30
	Arithmetic mean (AM)	24.13	24.25	23.63	23.75
	Geometric mean GM)a	24.00	24.13	23.47	23.53
Sarolaner	Range	0–13	0–8	0–0	0–0
	Arithmetic mean (AM)	5.13	1.63	0	0
	AM Efficacy (%)	78.87	93.30	100	100
	Geometric mean (GM)a	3.32	0.76	0	0
	GM Efficacy (%)	86.17	96.87	100	100
	Test statistic vs placebo	t (9) = 5.02	t (8) = 8.65	t (34) = 17.31	t (17) = 58.45
	P-value vs placebo	0.0007	< 0.0001	< 0.0001	< 0.0001
Afoxolaner	Range	10–28	1–13	0–2	0–0
	Arithmetic mean (AM)	20.13	5.00	0.38	0
	AM Efficacy (%)	17.01	79.38	98.41	100
	Geometric mean (GM)a	18.89	3.63	0.25	0
	GM Efficacy (%)	21.28	84.95	98.93	100
	Test statistic vs placebo	t (9) = 0.65	t (8) = 6.24	t (46) = 11.78	t (17) = 58.45
	P-value vs placebo	0.5302	0.0003	< 0.0001	< 0.0001
	Test statistic vs sarolaner	t (9) = 4.36	t (15) = 2.40	t (70) = 0.74	t (17) = 0.00
	P-value vs sarolaner	0.0018	0.0303	0.4622	1.0000

^a P-values are based on comparison of geometric means