Table 1.
Mean live Ixodes holocyclus counts and efficacy relative to placebo at 8, 12, 24 and 48 h after treatment for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0
Treatment | Tick counting time points post-treatment | ||||
---|---|---|---|---|---|
8 h | 12 h | 24 h | 48 h | ||
Placebo | Range | 21–28 | 20–28 | 19–28 | 19–30 |
Arithmetic mean (AM) | 24.13 | 24.25 | 23.63 | 23.75 | |
Geometric mean GM)a | 24.00 | 24.13 | 23.47 | 23.53 | |
Sarolaner | Range | 0–13 | 0–8 | 0–0 | 0–0 |
Arithmetic mean (AM) | 5.13 | 1.63 | 0 | 0 | |
AM Efficacy (%) | 78.87 | 93.30 | 100 | 100 | |
Geometric mean (GM)a | 3.32 | 0.76 | 0 | 0 | |
GM Efficacy (%) | 86.17 | 96.87 | 100 | 100 | |
Test statistic vs placebo | t (9) = 5.02 | t (8) = 8.65 | t (34) = 17.31 | t (17) = 58.45 | |
P-value vs placebo | 0.0007 | < 0.0001 | < 0.0001 | < 0.0001 | |
Afoxolaner | Range | 10–28 | 1–13 | 0–2 | 0–0 |
Arithmetic mean (AM) | 20.13 | 5.00 | 0.38 | 0 | |
AM Efficacy (%) | 17.01 | 79.38 | 98.41 | 100 | |
Geometric mean (GM)a | 18.89 | 3.63 | 0.25 | 0 | |
GM Efficacy (%) | 21.28 | 84.95 | 98.93 | 100 | |
Test statistic vs placebo | t (9) = 0.65 | t (8) = 6.24 | t (46) = 11.78 | t (17) = 58.45 | |
P-value vs placebo | 0.5302 | 0.0003 | < 0.0001 | < 0.0001 | |
Test statistic vs sarolaner | t (9) = 4.36 | t (15) = 2.40 | t (70) = 0.74 | t (17) = 0.00 | |
P-value vs sarolaner | 0.0018 | 0.0303 | 0.4622 | 1.0000 |
a P-values are based on comparison of geometric means