Table 2.
Mean live Ixodes holocyclus counts and efficacy relative to placebo at 12 h after weekly re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0
| Treatment | Day of study | |||||
|---|---|---|---|---|---|---|
| 7 | 14 | 21 | 28 | 35 | ||
| Placebo | Range | 16–28 | 22–28 | 17–26 | 19–27 | 23–28 |
| Arithmetic Mean (AM) | 21.75 | 25.25 | 23.75 | 23.13 | 25.13 | |
| Geometric Mean (GM)a | 21.44 | 25.16 | 23.56 | 22.99 | 25.09 | |
| Sarolaner | Range | 0–12 | 0–10 | 0–18 | 2–21 | 2–16 |
| Arithmetic mean (AM) | 3.00 | 3.00 | 4.88 | 10.75 | 8.75 | |
| AM Efficacy (%) | 86.21 | 88.12 | 79.47 | 53.51 | 65.17 | |
| Geometric mean (GM)a | 1.67 | 2.26 | 3.11 | 9.15 | 7.50 | |
| GM Efficacy (%) | 92.20 | 91.03 | 86.78 | 60.21 | 70.11 | |
| Test statistic vs placebo | t (8) = 6.26 | t (8) = 8.50 | t (8) = 5.41 | t (9) = 3.77 | t (8) = 4.97 | |
| P-value vs placebo | 0.0002 | < 0.0001 | 0.0007 | 0.0048 | 0.0012 | |
| Afoxolaner | Range | 2–16 | 7–20 | 10–22 | 15–28 | 16–27 |
| Arithmetic mean (AM) | 9.63 | 12.13 | 17.63 | 22.00 | 21.00 | |
| AM Efficacy (%) | 55.75 | 51.98 | 25.79 | 4.86 | 16.42 | |
| Geometric mean (GM)a | 8.36 | 11.49 | 17.03 | 21.66 | 20.78 | |
| GM Efficacy (%) | 61.01 | 54.31 | 27.69 | 5.78 | 17.17 | |
| Test statistic vs placebo | t (9) = 3.85 | t (10) = 6.26 | t (15) = 2.65 | t (17) = 0.67 | t (15) = 2.30 | |
| P-value vs placebo | 0.0042 | < 0.0001 | 0.0182 | 0.5138 | 0.0366 | |
| Test statistic vs sarolaner | t (13) = 3.16 | t (10) = 5.07 | t (9) = 4.37 | t (9) = 3.44 | t (8) = 4.10 | |
| P-value vs sarolaner | 0.0077 | 0.0004 | 0.0021 | 0.0070 | 0.0033 | |
a P-values are based on comparison of geometric means