Table 2.

Univariate and multivariable linear regression results. Multivariable estimates are adjusted for all other predictors

Predictor	Unadjusted change in WMH volume at 1 year per unit change in predictor (95% CI)	Unadjusted p value	Adjusted change in WMH volume at 1 year per unit change in predictor (95% CI)	Adjusted p value
Baseline WMH volume, ml	0.88 (0.84 to 0.93)	<0.0001	0.73 (0.65 to 0.80)	<0.0001
Age	0.91 (0.64 to 1.17)	<0.0001	−0.02 (−0.14 to 0.10)	0.75
MAP	−0.11 (−0.33 to 0.11)	0.31	−0.10 (−0.19 to −0.02)	0.013
PP	0.19 (0.035 to 0.35)	0.017	0.03 (−0.03 to 0.10)	0.34
Hypertension	4.89 (−2.77 to 12.54)	0.21	−1.40 (−4.06 to 1.26)	0.30
Fazekas score	11.54 (10.43 to 12.65)	<0.0001	2.93 (1.76 to 4.10)	<0.0001
Stroke subtype	0.88 (−5.83 to 7.58)	0.80	−0.85 (−3.05 to 1.34)	0.44
Smoking status	−2.30 (−9.16 to 4.56)	0.51	0.17 (−2.24 to 2.57)	0.89
Diabetes	10.36 (−0.19 to 20.90)	0.054	−1.98 (−5.51 to 1.54)	0.27
Hyperlipidaemia	−0.51 (−7.36 to 6.34)	0.88	−1.10 (−3.40 to 1.19)	0.34

Abbreviations: MAP Mean arterial pressure, PP Pulse pressure, WMH White matter hyperintensity