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Transition chart for the natural history of chronic hepatitis C. All transitions occur according to exponential probability distributions. Fibrosis progression is quantified using Metavir Score [42]: F0 = No fibrosis, F1 = Portal fibrosis without septa, F2 = portal fibrosis with few septa, F3 = numerous septa without cirrhosis, F4 = cirrhosis. Metavir fibrosis scores F0 and F1 (respectively F2 and F3) were gathered in a F0/1 (respectively F2/3) state
