Table 1.
The characteristics of included studies
| Study (year) | Number | Mean age | Anesthesia methods | TXA intervention | Prosthesis type | Thromboprophylaxis | Transfusion criteria |
|---|---|---|---|---|---|---|---|
| Xie 2016 [26] | 70/70/70(T/I/C) | 62.2/59.5/60.5(T/I/C) | General anesthesia | T:3 g; I: 1.5 g; C:1 g (IV) + 2 g (T) | Cementless | Enoxaparin + Physical therapy | Hb <7 g/dL |
| Yue 2015 [21] | 136/238/357(T/I/C) | 60.3/62.6/61.9(T/I/C) | – | T:3 g; I:15 mg/kg; TXA; C:15 mg/kg(IV) + 1.5 g (T) | Cementless | Low-molecular-weight heparin + Physical therapy | Hb <7 g/dL |
| Zhang 2015 [20] | 34/34/34(T/I/C) | 65.2/63.4/64.7(T/I/C) | – | T:0.1 g; I: l g; C:1 g(IV) + 0.1 g(T) | Cemented | Enoxaparin + rivaroxaban | Hb <7 g/dL |
| Zhao 2015 [25] | 44/48/44(T/I/C) | 62.2/59.8/57.6(T/I/C) | Continuous epidural anesthesia | T:1 g; I:1 g; C:1 g(IV) + 1 g(T) | Cementless | Rivaroxaban + Physical therapy | Hb < 8 g/dL |
| Lu 2016 [22] | 141/141/141(T/I/C) | 66.8/66.0/65.0(T/I/C) | General anesthesia | T: 2 g; I: 30 mg/kg TXA; C:30 mg/kg (IV) + 2 g (T) | Cementless | – | Hb <7 g/dL |
| Zhu 2016 [23] | 20/20/20(T/I/C) | 58.0/60.4/62.0(T/I/C) | – | T: 2 g; I: 15 mg/kg TXA; C:15 mg/kg (IV) + 2 g (T) | Cementless | – | – |
| Zeng 2016 [24] | 50/50(/I/C) | 54.0/53.6(/I/C) | – | I:15 mg/kg TXA; C:15 mg/kg (IV) + 1 g (T) | – | Low-molecular-weight heparin + Physical therapy | Hb <7 g/dL |
C combined group, T topical group, I intravenous group, IV intravenous injection, Hb hemoglobin