Fig. 1.

Linkage disequilibrium (LD) plots of single-nucleotide polymorphisms (SNPs) of genes in the same chromosome, i.e. TCF7L2, HHEX; IGF2BP2, PPARG; IRS1, CAPN10; CDKAL1. *D’ values mentioned in the linkage disequilibrium plot, except in two cases where the linkage disequilibrium was complete (100%). The pairs of SNPs with D’ value ≥ 80 per cent are considered to be in significant LD. Linkage disequilibrium is seen only between SNPs of the same gene, not across the genes, even on the same chromosome. The r² values for the above linkage disequilibrium plot ranged from 0.44 to 0.98, but in case of CAPN10, it was very low (r² = 0).