Table 4.
Hematological analysis of drug and radiation treated mice
| High TRIO | Int. TRIO | Low TRIO | Vehicle | PTX | P/17 | P/R | 17/R | TRIO+XRT | Vehicle+XRT | TRIO Day6 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| RBC [106/μL] | 8.8±0.2 | 8.3±0.3 | 8.5±0.1 | 8.7±0.2 | 8.4±0.1 | 8.0±0.3 | 8.0±0.1*** | 8.4±0.3 | 8.5±0.4 | 7.9±0.2*** | 8.3±0.4 |
| HGB [g/dL] | 14.7±0.4 | 13.9±0.3*** | 14.2±0.2 | 15.3±0.5 | 14.9±0.2 | 14±1 | 14.1±0.1 | 14.5±0.5 | 11±3 | 13.3±0.3*** | 13.9±0.4 |
| HCT [%] | 43±1 | 42±1 | 42±1 | 45±1 | 43±1 | 42±2 | 41.8±0.3 | 44±1 | 42±2 | 39±1** | 42±1 |
| PLATELET [103/μL] | 960±50 | 1049±45 | 1146±92 | 643±194 | 902±122 | 702±158 | 755±83 | 1153±109 | 765±61 | 1030±108 | 1428±3 |
| WBC [103/μL] | 5.3±0.5 | 9.4±3.3 | 8.0±0.9*** | 4.5±0.6 | 2.7±0.2*** | 3.5±0.9 | 2.1±0.2** | 6.7±0.9 | 0.8±0.0** | 0.8±0.0*** | 5.8±1.6 |
| Sodium [mmol/L] | 145±1 | 150±0 | 146±1 | 146±1 | 143±1 | 142±0.3*** | 144±1 | 140±1** | 146±1 | 146±1 | 148±1 |
| Potassium [mmol/L] | 3.8±0.3 | 3.6±0.3 | 3.2±0.3 | 3.6±0.1 | 3.6±0.1 | 3.9±0.3 | 3.6±0.1 | 3.7±0.3 | 4.0±0.2 | 4.0±0.3 | 3.7±0.1 |
| Chloride [mmol/L] | 112±1 | 112±0 | 113±1 | 114±1 | 116±1 | 114±1 | 118±1** | 113±1 | 113±1 | 114±0 | 115±0.4 |
| Total CO2 [mmol/L] | 17±1 | 18±1*** | 16±1 | 15±1 | 12.3±0.3*** | 13±1 | 11±1*** | 14.0±0.4 | 17±3 | 12.5±0.5*** | 10±1* |
| Anion Gap | 20±1 | 19±1 | 20±2 | 21±2 | 18.7±0.3 | 18±2 | 19.0±0.4 | 17±1 | 20±2 | 24±1 | 26±1*** |
| Calcium [mg/dL] | 9.5±0.1** | 9.0±0.1 | 9.0±0.1 | 8.9±0.0 | 9.4±0.0* | 9.4±0.1*** | 8.9±0.1 | 9.4±0.2 | 9.2±0.1 | 8.4±0.2*** | 8.8±0.1 |
| Phosphorus [mg/dL] | 6.4±0.8 | 6.0±0.4 | 5.2±1.1 | 9.2±1.7 | 8.4±0.4 | 8.1±0.8 | 8.0±0.7 | 6.7±0.3 | 6.7±0.4 | 6.4±0.3 | 7.1±0.6 |
| Magnesium [mg/dL] | 2.1±0.1 | 2.5±0.1 | 2.3±0.1 | 2.2±0.1 | 2.3±0.1 | 2.3±0.1 | 2.3±0.0 | 1.9±0.1 | 2.2±0.1 | 2.3±0.1 | 2.3±0.1 |
| Glucose [mg/dL] | 200±16 | 183±3 | 197±10 | 149±33 | 173±12 | 199±14 | 175±11 | 194±12 | 170±18 | 165±17 | 187±20 |
| Urea Nitrogen [mg/dL] | 22±1* | 25±1* | 22±1* | 15.3±0.3 | 23±2*** | 17±2 | 24±1* | 17±1 | 17.7±0.3** | 25±2*** | 20.3±0.6* |
| Creatinine [mg/dL] | 0.3±0.0 | 0.2±0.0 | 0.2±0.0 | 0.2±0.0 | 0.2±0.0 | 0.2±0.0 | 0.2±0.0 | 0.2±0.0 | 0.3±0.0 | 0.2±0.0 | 0.2±0.0 |
| Total Protein [g/dL] | 4.5±0.1*** | 4.3±0.1 | 4.5±0.1*** | 4.2±0.1 | 4.4±0.1 | 4.2±0.2 | 4.1±0.1 | 4.3±0.1 | 4.8±0.2*** | 4.2±0.1 | 4.4±0.1 |
| Albumin [g/dL] | 2.1±0.1 | 2.0±0.0 | 2.1±0 | 2.0±0.0 | 2.1±0.1 | 2.1±0.1 | 2.0±0.1 | 2.1±0.0 | 2.1±0.1 | 2.0±0.1 | 2.0±0.1 |
| Globulin [g/dL] | 2.4±0.1 | 2.3±0.1 | 2.4±0.1 | 2.2±0.1 | 2.3±0.1 | 2.1±0.1 | 2.1±0.1 | 2.2±0.0 | 2.8±0.1*** | 2.2±0.1 | 2.4±0.1 |
| AST [U/L] | 137±10*** | 170±31*** | 86±5 | 88±12 | 97±7 | 113±5 | 97±18 | 90±14 | 125±26 | 86±20 | 58±6 |
| ALT [U/L] | 51±3 | 50±5 | 43±2 | 46±1 | 50±2 | 55±3 | 52±3 | 45±1 | 42±3 | 45±4 | 38±1* |
| Alkaline Phosphatase [U/L] | 74±8 | 62±7 | 75±11 | 63±4 | 68±9 | 80±10 | 71±7 | 66±4 | 60±2 | 84±8 | 67±3 |
| Total Bilirubin [mg/dL] | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. |
| Cholesterol [mg/dL] | 86±5 | 87±5 | 92±4*** | 78±4 | 111±4*** | 91±10 | 88±4 | 101±1* | 126±9** | 73±1 | 96±6 |
| Triglycerides [mg/dL] | 98±18 | 117±9 | 105±18 | 93±3 | 181±32 | 82±5 | 121±4* | 128±16 | 202±46 | 99±14 | 189±44 |
*
:Significantly different from vehicle group (P<0.005)
**
: Significantly different from vehicle group (P<0.01)
***
:Significantly different from vehicle group (P<0.05)
RBC: Red blood cell count, HGB: Hemoglobin, HCT: Hematocrit, WBC: White blood cell count