Figure 2. Detailed Views of the Interactions between CD59 and the CDCs.

The proteins were oriented by superimposing the CD59^D22A molecule of the VLY^ml-CD59^D22A complex onto the CD59^D22A of the ILY^ml-CD59^D22A complex. Interfacial residues mentioned in the text are shown with key residues labeled, with those from CD59^D22A in italics. The UDP loop is labeled with the Thr-Leu cholesterol-recognition motif (CRM) residues on L1 indicated.

(A–C) VLY^ml (blue) and CD59^D22A (gray).

(D–F) ILY^ml (green) and CD59^D22A (orange).

Close-up views are shown of the CD59^D22A-CDC interfaces for VLY^ml (B and C) and ILY^ml (E and F) with the Y-X-Y-X₁₄-R-S CD59-motif residues and their contact residues in CD59^D22A labeled.

See also Figures S2, S5, and S6.