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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Nat Genet. 2016 Sep 12;48(10):1162–1170. doi: 10.1038/ng.3660

Figure 1. Overall study design.

Figure 1

In the discovery phase, single variant and gene-based analyses were performed for systolic and diastolic blood pressure, pulse pressure, mean arterial pressure, and hypertension among 146,562 individuals from the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus (CHARGE+) Exome Chip Blood Pressure Consortium. Fifteen variants were significant (P<3.4×10−7) and 62 displayed P<1×10−5. In the follow-up phase, meta-analysis was performed for 77 variants with results from 180,726 individuals from the CHD Exome+ Consortium, ExomeBP Consortium, GoT2DGenes Consortium, T2D–GENES consortium.