Skip to main content
. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Nat Genet. 2016 Sep 12;48(10):1162–1170. doi: 10.1038/ng.3660

Figure 2. NPR1 Gene: Low-frequency and rare variants associated in aggregate with mean arterial pressure.

Figure 2

The NPR1 protein (1,061 amino acids) is comprised of three domains: extracellular domain, kinase homology domain, and guanylate cyclase domain. The effects of the 14 low-frequency and rare variants after adjustment for age, age2, sex, and body mass index on mean arterial pressure are shown for higher (tan) or lower (purple) values in mm Hg; dot area is proportional to the number of minor allele carriers. The minor allele of rs35479618 (MAF ∼ 0.012, E967K), was carried by 3,164 participants. The minor allele of rs201787421 (MAF ∼ 2.6×10−5 R782Q), was carried by 5 participants.