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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Nat Genet. 2016 Sep 12;48(10):1162–1170. doi: 10.1038/ng.3660

Figure 3. DBH Gene: Rare variants associated in aggregate with mean arterial pressure.

Figure 3

The DBH protein (617 amino acids) contains the dopamine β-monooxygenase N-terminal (DOMON) domain, the catalytic core (the CuH and CuM domains) and the C-terminal (C–T) domain. The effects of the 27 rare variants after adjustment for age, age2, sex, and body mass index on mean arterial pressure are shown for higher (tan) or lower (purple) values in mm Hg. The minor allele of rs74853476 (MAF ∼ 0.0015), a splicing variant, was carried by 291 participants. The minor allele of rs201681337 (MAF ∼ 7.9×10−5, A301T), was carried by 4 participants.