Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jan 31;114(7):1560–1565. doi: 10.1073/pnas.1615310114

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

PMC Copyright notice

Fig. 4. — CRY1 PHR is compact and CLOCK:BMAL1 bHLH-PAS-AB dimer is highly flexible in solution. (A) SAXS profile for CRY1 PHR (black) compared with the theoretical scattering profile for CRY1 PHR (PDB ID code 5T5X) calculated by the FoXS server (orange). Residuals for the fit are shown below with an overall χ = 1.13. (B) The crystal structure of CRY1 PHR fit into the solution envelope generated from the SAXS data. (C) SAXS profile for the CLOCK:BMAL1 PAS-AB dimer (black) compared with the theoretical scattering profile calculated from PDB ID code 4F3L by the FoXS server (orange). Multistate modeling of flexible regions within the dimer was performed with HingeProt paired with MultiFoXS. (D) A representative PDB from the top MultiFoXS hit that includes flexible loops not visible in the crystal structure (gray) aligned with PDB ID code 4F3L using the PAS-A domain of BMAL1; CLOCK, green; BMAL1, blue. Arrows indicate regions of predicted flexibility.