Fig. 4.
The Gatmc/c mice exhibit normal peripheral immune homeostasis and responses. (A) Flow cytometry analysis of peripheral blood B cells (B220+), CD4+ T cells (CD3+ CD4+), CD8+ T cells (CD3+CD8+), macrophages (F480+), neutrophils (CD11b+F480−) and NK cells (NK1.1+CD3−) in Gatm+/+ (n = 6), Gatmc/+ (n = 9), and Gatmc/c (n = 5) mice. (B and C) Serum NP-specific IgM (B) and β-gal–specific IgG (C) measured by ELISA in Gatm+/+ (n = 6), Gatmc/+ (n = 9), and Gatmc/c (n = 5) mice immunized 5 or 14 d before with NP-Ficoll and rSFV–β-gal, respectively. Bars indicate mean ± SD. Differences between genotypes were not found to be statistically significant (P > 0.05).