Table 2.

Candidate mutations in the DSS colitis screen

Gene	Mutation	Inheritance	Ref	Het	Var	P
1700112E06Rik	Y13*	Recessive	20	24	5	1.22E-08
Cars	E430G	Recessive	9	14	2	6.17E-09
Col3a1	Splice donor	Recessive	19	17	2	1.30E-06
Col4a1	G1341V	Dominant	7	9	0	1.34E-05
Degs2	N189D	Recessive	8	9	6	4.40E-05
Ern2	Splice donor	Recessive	12	20	10	2.20E-10
Gatm	D254G	Recessive	8	7	6	5.56E-09
Glyat	V247F	Recessive	10	7	3	1.79E-06
Gpat2†	V75M	Recessive	11	16	10	1.84E-05
Hesx1†	W45R	Dominant	6	9	2	4.51E-06
Hgf	H649L	Recessive	6	10	2	8.11E-09
Hr	L1091P	Recessive	5	15	5	1.91E-07
Hsd11b2	V270E	Recessive	2	6	4	2.44E-09
Klf5	R360C	Additive	24	29	5	1.78E-07
Lars2	I305N	Recessive	3	10	4	6.09E-08
Lck†	E299G	Recessive	2	9	6	2.07E-06
Liph	I204N	Recessive	15	25	5	6.12E-07
Lrba	Q1292*	Recessive	16	11	5	2.98E-06
Mnd1	C62F	Recessive	18	14	3	4.55E-05
Mtif3	R249S	Recessive	8	7	2	8.10E-06
Myo1d	L972P	Recessive	12	19	10	1.47E-09
Nlrp4d	K762N	Recessive	5	19	4	1.88E-05
Rnps1	F181I	Recessive	27	23	4	1.41E-06
Smcr8	I2T	Recessive	10	13	3	6.41E-08
Smcr8	M1V	Recessive	6	13	4	7.71E-06
Yap1	G36D	Additive	4	7	8	3.39E-05
Zfp219†	T595S	Dominant	9	16	3	5.01E-06

Ref, wild type; Het, heterozygous; Var, homozygous variant.

^*Stop codon.

^†Genes conferred resistance to DSS-induced colitis.