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Scheme for synthesis of acceptor B. Reagents and conditions. (a) H2NNH2⋅H2O, AcOH, pyridine, room temperature (rt), 1 h, 95%. (b) TMSOTf, MS4Å, CH2Cl2, –10 °C, 1 h, 72%. (c) (i) Ethylenediamine, n-BuOH, 80 °C, overnight; (ii) Ac2O, pyridine, rt, overnight, 88% (two steps). (d) (i) Eighty percent AcOH aq., 60 °C, 7 h; (ii) Ac2O, pyridine, rt, overnight, 85% (two steps). (e) NaOMe, MeOH, rt, overnight, 88%. (f) Pd/C, H2, H2O, rt, overnight, 93%. (g) FITC, DIPEA, DMF, rt, overnight, 52%.
