Table S4.

Structure–activity relationships of 15 analogs

For each analog, only the modified region is illustrated. No illustration represents no change in the indicated region. Values are expressed as percentages of the 15 blockade level in each assay and represent mean ± SEM obtained from at least three independent experiments. Statistical analyses were performed as described in SI Materials and Methods. **P <0.01; ***P <0.001 compared with the value obtained with 15, which is normalized to 100%.