Fig 1.

(A) Effect of food on the exposure (area under the curve [AUC]) of selinexor as a function of time (0 to 24 hours). Plasma concentration of selinexor (first-generation tablet or capsule; 30 mg/m²) over 24 hours when administered under fasting conditions or in conjunction with a low- or high-fat meal (cohort one). AUCs for all fed conditions were significantly higher compared with that for the fasting state (P < .05). (B) Effect of formulation on the exposure (AUC) of selinexor as a function of time (0 to 48 hours). Comparison of selinexor (60 mg) pharmacokinetics for first- and second-generation tablets and oral suspension over 48 hours (cohort three).