Table 3.
Effect of First-Line Chemotherapy on Change in EGFR Mutation in Plasma Samples Before and After Treatment and Association With Tumor Response (n = 264)
| EGFR Mutation Change From Pre- to Postchemotherapy | Tumor Response |
Total (n = 264) |
||||||
|---|---|---|---|---|---|---|---|---|
| PR |
SD |
PD |
||||||
| No. | % | No. | % | No. | % | No. | % | |
| Mutation → wild type* | 21 | 38.9 | 26 | 48.1 | 7 | 13.0 | 54 | 100.0 |
| No change | 56 | 30.1 | 86 | 46.2 | 44 | 23.7 | 186 | 100.0 |
| Wild → mutation* | 5 | 20.8 | 13 | 54.2 | 6 | 25.0 | 24 | 100.0 |
Abbreviations: PD, progressive disease; PR, partial response; SD, stable disease.
*
P = .037 (Cochran-Armitage trend test).