Table 4.
Cetuximab Dose | No. of Patients | AUC(0-inf) (μg/mL • h) |
Clearance (L/h • m2) |
Vdss (L/m2) |
|||
---|---|---|---|---|---|---|---|
Mean* | CV (%) | Mean† | SD | Mean† | SD | ||
75 mg/m2 | |||||||
Ages 1-12 years | 7 | 1,598 | 48 | 0.057 | 0.041 | 2.081 | 0.666 |
Ages 13-18 years | 4 | 1,925 | 23 | 0.040 | 0.010 | 2.138 | 0.453 |
150 mg/m2 | |||||||
Ages 1-12 years | 7 | 8,871 | 21 | 0.017 | 0.004 | 1.860 | 0.564 |
Ages 13-18 years | 2 | 7,027 | 3 | 0.021 | 0.001 | 1.887 | 0.262 |
250 mg/m2 | |||||||
Ages 1-12 years | 9 | 17,706 | 34 | 0.015 | 0.005 | 2.157 | 0.362 |
Ages 13-18 years | 6 | 13,410 | 38 | 0.020 | 0.009 | 2.179 | 0.250 |
Abbreviations: AUC, area under the curve; Vdss, volume of distribution at steady state; CV, coefficient of variation; SD, standard deviation; inf, infinity.
Geometric mean for AUC(0-inf).
Arithmetic mean for clearance and Vdss.