Table 4.

Summary of Selected Cetuximab Pharmacokinetic Parameters

Cetuximab Dose	No. of Patients	AUC(0-inf) (μg/mL • h)		Clearance (L/h • m2)		Vdss (L/m2)
		Mean*	CV (%)	Mean†	SD	Mean†	SD
75 mg/m2
Ages 1-12 years	7	1,598	48	0.057	0.041	2.081	0.666
Ages 13-18 years	4	1,925	23	0.040	0.010	2.138	0.453
150 mg/m2
Ages 1-12 years	7	8,871	21	0.017	0.004	1.860	0.564
Ages 13-18 years	2	7,027	3	0.021	0.001	1.887	0.262
250 mg/m2
Ages 1-12 years	9	17,706	34	0.015	0.005	2.157	0.362
Ages 13-18 years	6	13,410	38	0.020	0.009	2.179	0.250

Abbreviations: AUC, area under the curve; Vd_ss, volume of distribution at steady state; CV, coefficient of variation; SD, standard deviation; inf, infinity.

^*Geometric mean for AUC_(0-inf).

^†Arithmetic mean for clearance and Vd_ss.