Figure 1.

Spatial learning ability and behavior pattern of 3×Tg mice. GTM-1, Rap, and CBZ can significantly restore the spatial learning and memory deficits assessed by the Morris water maze test. (A) Latency in seconds for finding the hidden platform over the 5-day period test. (B) Swim speed of mice in each group did not change significantly. (C–D) The percentage of time in target quadrant and the number of crossing were significantly improved by GTM-1, Rap, and CBZ compared with the vehicle group. * Represents P<0.05, ** represents P<0.001.