Table 2. Rates and hazard ratios of dementia in patients with non-melanoma skin cancer compared with members of a matched comparison cohort, Denmark, 1980–2013.
| NMSC cohort | Comparison cohort | Unadjusted HR (95% CI)† | Adjusted HR (95% CI)‡ | |||
|---|---|---|---|---|---|---|
| No. of events | Rate (95% CI)* | No. of events | Rate (95% CI)* | |||
| Any NMSC | ||||||
| Alzheimer’s disease | 4,179 | 2.51 (2.43–2.59) | 20,975 | 2.58 (2.54–2.61) | 0.95 (0.91–0.98) | 0.95 (0.92–0.98) |
| All-cause dementia | 11,681 | 7.01 (6.89–7.14) | 59,667 | 7.34 (7.28–7.39) | 0.92 (0.90–0.94) | 0.92 (0.90–0.94) |
| Basal cell carcinoma | ||||||
| Alzheimer’s disease | 3,506 | 2.39 (2.31–2.47) | 17,136 | 2.43 (2.39–2.47) | 0.94 (0.91–0.98) | 0.95 (0.91–0.98) |
| All-cause dementia | 9,745 | 6.65 (6.52–6.78) | 48,631 | 6.90 (6.84–6.96) | 0.91 (0.89–0.94) | 0.92 (0.90–0.94) |
| Squamous cell carcinoma | ||||||
| Alzheimer’s disease | 564 | 3.67 (3.37–3.98) | 3,160 | 3.85 (3.72–3.99) | 0.95 (0.86–1.05) | 0.95 (0.86–1.05) |
| All-cause dementia | 1,634 | 10.64 (10.12–11.16) | 9,228 | 11.26 (11.03–11.49) | 0.94 (0.88–0.99) | 0.94 (0.88–0.99) |
Abbreviations: CI = confidence interval; HR = hazard ratio; NMSC = non-melanoma skin cancer
* Rate per 1,000 person-years.
†Computed using stratified Cox proportional hazard regression adjusted by study design for age, sex, and calendar period of the skin cancer diagnosis/index date.
‡Adjusted additionally for alcohol-related diagnoses, hospital-diagnosed obesity, hypertension, ischemic heart disease (angina pectoris, myocardial infarction, and percutaneous coronary intervention), congestive heart failure, peripheral artery disease, chronic pulmonary disease, diabetes, cancer, and multiple sclerosis