Table 3. Clinical factors associated with primary outcome in the study cohort.
| Variables | Univariable analysis | *Multivariable analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age (years) | 1.06 | 1.03–1.08 | < 0.001 | 1.04 | 1.01–1.07 | 0.01 |
| Sex (male) | 1.34 | 0.83–2.17 | 0.24 | 1.83 | 1.07–3.11 | 0.03 |
| Creatinine (mg/dL) | 1.31 | 0.96–1.79 | 0.09 | 1.03 | 0.55–1.92 | 0.93 |
| Hypertension | 1.39 | 0.79–2.44 | 0.26 | 1.42 | 0.43–4.71 | 0.57 |
| Diabetes mellitus | 2.48 | 1.29–4.77 | 0.006 | 1.70 | 0.90–3.20 | 0.10 |
| Albumin (g/L) | 0.18 | 0.11–0.29 | < 0.001 | 0.37 | 0.19–0.71 | 0.003 |
| Bilirubin 0.8–1.2 mg/dL | 0.29 | 0.17–0.50 | < 0.001 | 0.33 | 0.19–0.59 | < 0.001 |
HR, hazard ratio, CI, confidence interval, eGFR, estimated glomerular filtration rate
*Adjusted with age, sex, creatinine, calcium, albumin, AST, ALT, total cholesterol, baseline use of ACE I/ARBs, diuretics, statins, history of hypertension, diabetes mellitus, and cancer. All serum parameters were included in the analysis as continuous variables (natural unit).