Table 1. Summary of renal effects of maternal obesity, diet-induced obesity and streptozotocin (100mg/kg once) (STZ).

	Maternal obesity	Diet-induced obesity	Diet-induced obesity + STZ	Maternal obesity + diet-induced obesity ± STZ
Kidney function / structural change	↑	↑	↔	↔
Renal fibrotic markers	↑	↑	↔	↔
Inflammatory markers	↑	↑↑	↔	↔
Oxidative stress markers	↑	↑↑	↔	↔

Our results demonstrate that maternal obesity has a sustained effect on renal function and structure independent of diet-induced obesity. However, diet-induced obesity in adulthood has a more potent effect on renal consequences, irrespective of maternal obesity with or without STZ. ↔ denotes no added effect of STZ or maternal obesity beyond that which is demonstrated with diet-induced obesity alone.