Si
|
Susceptible individuals |
|
Number |
|
Ii
|
Infected but not infectious |
|
Number |
|
IDi
|
Infected and Infectious (PCR and TF +ve) |
|
Number |
|
Di
|
Diseased and not infectious (TF +ve) |
|
Number |
|
PDi
|
Partially diseased can be re-infected (TF +ve) |
|
Number |
|
IOi
|
Infected and infectious (PCR +ve) |
|
Number |
|
β |
Transmission rate parameter |
Estimated |
Proportion |
|
ϵ |
Degree of random mixing in the population |
0.5 |
Proportion |
[11] |
c |
Coverage level of treatment |
80% |
Percentage |
|
e |
Efficacy of treatment |
85% |
Percentage |
[12, 31] |
Ninfs
|
Maximum number of infections before immunity saturates |
100 |
Number |
[11] |
N |
Total number of individuals in the population |
6000 |
Number |
|
α |
Infectivity of an individual proportional to the log of their bacterial load |
0–1 |
Proportion |
[11] |
ρ1
|
Minimum rate of recovery from active disease after 1st infection |
Estimated |
Day−1
|
[8, 11] |
ρ100
|
Maximum rate of recovery from active disease after 100th infection |
1/7 |
Day−1
|
[8, 11] |
ω1
|
Minimum rate of recovery from 1st infection |
Estimated |
Day−1
|
[8, 11] |
ω100
|
Maximum rate of recovery from 100th infection |
1/77 |
Day−1
|
[8, 11] |
θ |
Rate of change of the recovery from disease rate per infection |
0.30 |
Proportion |
[8, 11] |
ϕ |
Rate of change of the recovery from infection rate per infection |
0.45 |
Proportion |
[8] |
π |
Rate of change of infectivity rate per infection |
Estimated |
Proportion |
[8, 11] |
ψ |
Non-linear power term |
1.2, 1.4 |
Number |
[9] |
ζ1
|
Rate of recovery from PD with 1st infection |
1/134 |
Day−1
|
[8, 18] |
ζ100
|
Rate of recovery from PD with 100th infection |
1/7 |
Day−1
|
[8, 18] |
η1
|
Rate of recovery from IO with 1st infection |
1/77 |
Day−1
|
[8] |
η100
|
Rate of recovery from IO with 100th infection |
1/38 |
Day−1
|
[8] |
σ |
Rate at which infected individuals become infectious |
1/14 |
Day−1
|
[8] |
λa
|
Age-specific force of infection |
Calculated |
|
|
v2
|
Non-linear constant term |
2.6 |
Number |
[9] |
Γ |
Susceptibility to re-infection in the disease state |
0, 0.20, 0.50, 0.80 |
Proportion |
[18] |