Table 1. State variables, parameters definitions and values used in the model.
Where two numbers are listed for ψ, they indicate the values used for TF 40% and 20% communities.
Name | Definition | Value | Units | Source |
---|---|---|---|---|
Si | Susceptible individuals | Number | ||
Ii | Infected but not infectious | Number | ||
IDi | Infected and Infectious (PCR and TF +ve) | Number | ||
Di | Diseased and not infectious (TF +ve) | Number | ||
PDi | Partially diseased can be re-infected (TF +ve) | Number | ||
IOi | Infected and infectious (PCR +ve) | Number | ||
β | Transmission rate parameter | Estimated | Proportion | |
ϵ | Degree of random mixing in the population | 0.5 | Proportion | [11] |
c | Coverage level of treatment | 80% | Percentage | |
e | Efficacy of treatment | 85% | Percentage | [12, 31] |
Ninfs | Maximum number of infections before immunity saturates | 100 | Number | [11] |
N | Total number of individuals in the population | 6000 | Number | |
α | Infectivity of an individual proportional to the log of their bacterial load | 0–1 | Proportion | [11] |
ρ1 | Minimum rate of recovery from active disease after 1st infection | Estimated | Day−1 | [8, 11] |
ρ100 | Maximum rate of recovery from active disease after 100th infection | 1/7 | Day−1 | [8, 11] |
ω1 | Minimum rate of recovery from 1st infection | Estimated | Day−1 | [8, 11] |
ω100 | Maximum rate of recovery from 100th infection | 1/77 | Day−1 | [8, 11] |
θ | Rate of change of the recovery from disease rate per infection | 0.30 | Proportion | [8, 11] |
ϕ | Rate of change of the recovery from infection rate per infection | 0.45 | Proportion | [8] |
π | Rate of change of infectivity rate per infection | Estimated | Proportion | [8, 11] |
ψ | Non-linear power term | 1.2, 1.4 | Number | [9] |
ζ1 | Rate of recovery from PD with 1st infection | 1/134 | Day−1 | [8, 18] |
ζ100 | Rate of recovery from PD with 100th infection | 1/7 | Day−1 | [8, 18] |
η1 | Rate of recovery from IO with 1st infection | 1/77 | Day−1 | [8] |
η100 | Rate of recovery from IO with 100th infection | 1/38 | Day−1 | [8] |
σ | Rate at which infected individuals become infectious | 1/14 | Day−1 | [8] |
λa | Age-specific force of infection | Calculated | ||
v2 | Non-linear constant term | 2.6 | Number | [9] |
Γ | Susceptibility to re-infection in the disease state | 0, 0.20, 0.50, 0.80 | Proportion | [18] |