Table 5. Multivariable logistic regression analysis of SNP-age interaction models for four key SNPs within the ADAMTS9 gene.
| SNP-age interaction model | OR | 95% CI | P valueb |
|---|---|---|---|
| (a) ADAMTS9 rs73832338 | |||
| ADAMTS9 rs73832338 (CC genotype) with Age ≦ 64 years olda | 1 | ||
| ADAMTS9 rs73832338 (CC genotype) with Age > 64 years old | 0.76 | 0.45–1.28 | 0.3014 |
|
ADAMTS9 rs73832338 (TT+TC genotype) with Age ≦ 64 years old |
4.90 | 1.82–13.16 | 0.0016 |
|
ADAMTS9 rs73832338 (TT+TC genotype) with Age > 64 years old |
1.30 | 0.67–2.55 | 0.4408 |
| (b) ADAMTS9 rs9985304 | |||
| ADAMTS9 rs9985304 (AA genotype) with Age ≦ 64 years olda | 1 | ||
| ADAMTS9 rs99853048 (AA genotype) with Age > 64 years old | 1.18 | 0.50–2.75 | 0.7063 |
| ADAMTS9 rs9985304 (GG+AG genotype) with Age ≦ 64 years old | 6.51 | 3.08–13.73 | 8.8 x 10−7 |
| ADAMTS9 rs9985304 (GG+AG genotype) with Age > 64 years old | 2.67 | 1.35–5.26 | 0.0045 |
| (c) ADAMTS9 rs4317088 | |||
| ADAMTS9 rs4317088 (CC genotype) with Age ≦ 64 years olda | 1 | ||
| ADAMTS9 rs4317088 (CC genotype) with Age > 64 years old | 0.86 | 0.40–1.86 | 0.7098 |
| ADAMTS9 rs4317088 (TT+TC genotype) with Age ≦ 64 years old | 4.86 | 2.36–9.98 | 1.7 x 10−5 |
| ADAMTS9 rs4317088 (TT+TC genotype) with Age > 64 years old | 2.05 | 1.08–3.88 | 0.0276 |
| (d) ADAMTS9 rs9831846 | |||
| ADAMTS9 rs9831846 (CC genotype) with Age ≦ 64 years olda | 1 | ||
| ADAMTS9 rs9831846 (CC genotype) with Age > 64 years old | 0.71 | 0.33–1.56 | 0.3967 |
| ADAMTS9 rs9831846 (TT+TC genotype) with Age ≦ 64 years old | 3.11 | 1.52–6.39 | 0.0019 |
| ADAMTS9 rs9831846 (TT+TC genotype) with Age > 64 years old | 1.65 | 0.85–3.21 | 0.1385 |
CI = confidence interval, OR = odds ratio.
a Reference.
b Versus reference.
Analysis was obtained after adjustment for covariates including gender and education. P values of < 0.05 are shown in bold.