Table 1.

Heterozygous carrier frequencies of the CEL-HYB variant in German and French subjects with chronic pancreatitis

Patient materials*	Cases		Controls
	+/N	%	+/N	%	OR	CI	P value**
Discovery cohort	10/71	14.1	5/478	1.0	15.5	5.1 – 46.9	1.3 × 10-6
Non-alcoholic CP cohort 1	11/260	4.2	5/569	0.9	5.0	1.7 – 14.5	0.002
Non-alcoholic CP cohort 2	22/510	4.3	16/2362	0.7	6.6	3.4 – 12.7	1.3 × 10−8
Non-alcoholic CP cohort 3	9/352	2.6	9/1221	0.7	3.5	1.4 – 9.0	0.009
Meta-analysis ***	-	-	-	-	5.2	3.2 - 8.5	1.2 × 10−11
Alcoholic CP cohort	15/853	1.8	26/3409	0.8	2.3	1.2 – 4.4	0.016

^*Cohorts are described in the Methods section

^**Two-tailed Fisher’s exact test

^***Fixed effect model (in replication cohorts only). Z= 6.78; heterogeneity chi-squared = 1.18 (d.f. = 3), P = 0.553; I-squared