Table 1.
Patient materials* | Cases |
Controls |
|||||
---|---|---|---|---|---|---|---|
+/N | % | +/N | % | OR | CI | P value** | |
Discovery cohort | 10/71 | 14.1 | 5/478 | 1.0 | 15.5 | 5.1 – 46.9 | 1.3 × 10-6 |
| |||||||
Non-alcoholic CP cohort 1 | 11/260 | 4.2 | 5/569 | 0.9 | 5.0 | 1.7 – 14.5 | 0.002 |
Non-alcoholic CP cohort 2 | 22/510 | 4.3 | 16/2362 | 0.7 | 6.6 | 3.4 – 12.7 | 1.3 × 10−8 |
Non-alcoholic CP cohort 3 | 9/352 | 2.6 | 9/1221 | 0.7 | 3.5 | 1.4 – 9.0 | 0.009 |
Meta-analysis *** | - | - | - | - | 5.2 | 3.2 - 8.5 | 1.2 × 10−11 |
| |||||||
Alcoholic CP cohort | 15/853 | 1.8 | 26/3409 | 0.8 | 2.3 | 1.2 – 4.4 | 0.016 |
Cohorts are described in the Methods section
Two-tailed Fisher’s exact test
Fixed effect model (in replication cohorts only). Z= 6.78; heterogeneity chi-squared = 1.18 (d.f. = 3), P = 0.553; I-squared