Table 2. Association between BCL11A genotypes and development of LSCC and vocal leukoplakia.
Genotype | Controls | LSCC | Vocal leukoplakia | ||||
---|---|---|---|---|---|---|---|
n = 310 | n = 330 | OR (95% CI) | P-value | n = 155 | OR (95% CI) | P-value | |
Rs11886868 | |||||||
CC | 302 | 310 | Referent | 144 | Referent | ||
CT | 7 | 19 | 2.64(1.10–6.38) | 0.025 | 11 | 3.30(1.25–8.68) | 0.011 |
TT | 1 | 1 | 0.97(0.06–15.65) | 1 | 0 | 1.00(0.99–1.00) | 1 |
Alleles | |||||||
C | 611 | 639 | Referent | 299 | Referent | ||
T | 9 | 21 | 2.23(1.01–4.91) | 0.041 | 11 | 2.50(1.02–6.09) | 0.038 |
Rs4671393 | |||||||
AA | 19 | 10 | Referent | 4 | Referent | ||
AG | 121 | 94 | 1.48(0.66–3.32) | 0.345 | 43 | 1.69(0.54–5.24) | 0.361 |
GG | 170 | 226 | 2.53(1.15–5.57) | 0.018 | 108 | 3.02(1.00–9.11) | 0.041 |
Alleles | |||||||
A | 159 | 114 | Referent | 51 | Referent | ||
G | 461 | 546 | 1.65(1.26–2.17) | 0.000 | 259 | 1.75(1.23–2.49) | 0.002 |