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. Author manuscript; available in PMC: 2017 Feb 22.
Published in final edited form as: Future Med Chem. 2016 May 19;8(13):1655–1680. doi: 10.4155/fmc-2016-0059

Figure 9. Bump-and-hole approach.

Figure 9

Superposition of the x-ray structure of the ET (in cyan) bound to the BRD2-BD2 L383A (in gray, PDB 4QEW) and parent ligand I-BET762 (in orange) bound to the BRD2-BD2 (not shown, PDB 5DFC).