Table 1.
Predictors of D14 BM blast clearance
| Characteristica | D14 BM blasts <10% (N= 319) |
D14 BM blasts 10–29% (N = 31) |
D14 BM blasts ≥30% (N = 39) |
P |
|---|---|---|---|---|
| Age (years) | 38 (13–86) | 31 (18–71) | 44 (19–79) | 0.04 |
| WBC (109/L) | 4.1 (0.4–420.0) | 6.9 (0.8–155.8) | 7.3 (0.9–602.4) | <0.01 |
| Hemoglobin (g/dL) | 9.4 (3.5–16.3) | 9.2 (6.8–14.8) | 9.0 (4.5–15.1) | 0.43 |
| Platelets (109/L) | 40 (1–513) | 41 (14–265) | 39 (7–188) | 0.68 |
| BM blasts (%) | 86 (25–100) | 85 (34–98) | 86 (39–98) | 0.32 |
| LDH (U/L) | 1060 (172–32029) | 855 (197–36630) | 1052 (339–4675) | 0.28 |
| PS | ||||
| 0–1 | 248 (81) | 27 (9) | 31 (10) | 0.78 |
| 2–4 | 45 (85) | 2 (4) | 6 (11) | |
| Diagnosis | ||||
| B-ALL | 276 (84) | 25 (8) | 28 (9) | 0.01 |
| T-ALL | 43 (72) | 6 (10) | 11 (18) | |
| Cytogenetics | ||||
| Poor-risk | 59 (84) | 8 (11) | 3 (4) | 0.32 |
| Others | 234 (82) | 20 (7) | 30 (11) | |
| Regimen | ||||
| Hyper-CVAD | 248 (82) | 19 (6) | 34 (11) | 0.61 |
| AugBFM | 71 (81) | 12 (14) | 5 (5) | |
a
Continuous variables are listed as median (range) and categorical variables as n (%)
D14, day 14; BM, bone marrow; WBC, white blood cells; BM, bone marrow; LDH, lactate dehydrogenase; PS, performance status; Hyper-CVAD, hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone; AugBFM, augmented Berlin-Frankfurt-Munster