Table 3.

Multivariate analysis for the risk of relapse or death among patient with adult Ph- ALL.

Variable	Hazard ratio (95% CI)	P
Risk of relapse or death
Age	1.01 (1.01-1.02)	0.03
WBC	1.24 (1.04-1.38)	0.01
Platelet count	1.20 (1.04-1.38)	0.01
Performance status ≥ 2	1.81 (1.12-2.92)	0.02
Ho-Tr	2.65 (1.28-5.52)	0.01
Complex karyotype	2.58 (1.39-4.80)	< 0.01
MRD positive	1.82 (1.24-2.68)	< 0.01
Risk of death
Age	1.02 (1.01-1.03)	< 0.01
WBC	1.17 (1.01-1.36)	0.04
Performance status ≥ 2	1.72 (1.03-2.86)	0.04
Ho-Tr	3.15 (1.40-7.09)	0.01
Complex karyotype	2.42 (1.26-4.66)	0.01
MRD positive	1.93 (1.27-2.92)	< 0.01

Ho-Tr, Low hpodiploidy/near-triploidy. WBC and platelet count were analyzed as log (WBC) and log (platelet). Decreased performance status was defined as ECOG PS ≥ 2. All cytogenetic subgroups were compared to the diploid subgroup.