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Schematic representation of stop codon suppression strategy. PylRS aminoacylates an orthogonal suppressor tRNA (anticodon CUA) with a non-cognate amino acid (ncAA). NcAA-tRNAPylCUA is delivered to the ribosome by the host elongation factor EF-Tu. At the ribosome, the ncAA-tRNAPylCUA decodes an internal stop codon (UAG) and the ncAA becomes incorporated in the protein of interest.
