Skip to main content
. Author manuscript; available in PMC: 2017 Feb 22.
Published in final edited form as: Croat Chem Acta. 2016 Jun 14;89(2):163–174. doi: 10.5562/cca2825

Figure 4.

Figure 4

NcAAs that can be co-translationally incorporated into proteins for bioorthogonal labelling through Cu(I) catalyzed cycloaddition (Nε-((prop-2-yn-1-yloxy)carbonyl)-l-lysine (1), Nε-((2-azidoethoxy)carbonyl)-l-lysine (2), Nε-((2R,3S)-3-ethynyltetrahydrofuran-2-carbonyl)-l-lysine (3), Nε-((S)-3-aminohex-5-ynoyl)-l-lysine (4)) or through inverse-electron-demand Diels–Alder reaction (Nε-((((R,E)-cyclooct-4-en-1-yl)oxy)carbonyl)-l-lysine (5), Nε-((cyclooct-2-yn-1-yloxy)carbonyl)-l-lysine (6), Nε-((((1R,8S)-bicyclo[6.1.0]non-4-yn-9-yl)methoxy)carbonyl)-l-lysine (7), Nε-((bicyclo[2.2.1]hept-5-en-2-ylmethoxy)carbonyl)-l-lysine (8)).