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. Author manuscript; available in PMC: 2017 Jul 11.
Published in final edited form as: Nature. 2017 Jan 11;542(7641):377–380. doi: 10.1038/nature21078

Figure 3. Proteins stabilise the repositioned branch helix.

Figure 3

a, Key proteins that interact with the branch helix in C* complex. Prp8RH, Prp8 RNaseH-like domain; Prp8EN, Prp8 Endonuclease domain; Prp8L, Prp8 Large domain. b, Key proteins that interact with the branch helix in C complex. Prp17 has undergone a dramatic repositioning between C and C* complexes. c, Surface representation of proteins that promote an undocked conformation of the branch helix. Slu7 and Prp18 bind on the surface of the Prp8 RNaseH domain. d, The Prp8 β-hairpin stabilises the reorganised interactions between the 5’-splice site and the ACAGAGA sequence of U6 snRNA.