Table 2.
MICs (mg/L) of polymyxin lipopeptides against Gram-negative bacteria (polymyxin-resistant isolates in red).
| Bacterial isolate | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polymyxin lipopeptide |
P. aeruginosa ATCC 27853 | P. aeruginosaFADDIPA001 | P. aeruginosa FADDI-PA025 | P. aeruginosa FADDI-PA070 | P.aeruginosa FADDI-PA060 | P. aeruginosa FADDI-PA090 | A. baumanniiATCC 19606 | A. baumanniiFADDI-AB110 | A. baumanniiATCC 17978 | A. baumanniiFADDI-AB065 | A. baumanniiFADDI-AB156 | A. baumanniiFADDI-AB167 | K. pneumoniae ATCC 13883 | K. pneumoniae FADDI-KP032 | K. pneumoniae FADDI-KP027 | K. pneumoniae FADDI-KP003 | K. pneumoniae FADDI-KP012 | E. cloacae FADDI-EC006 | E. cloacae FADDI-EC001 | E. cloacae FADDI-EC003 |
| Colistin | 1 | 1 | 2 | >128 | >128 | 8 | 1 | 0.5 | 0.5 | 128 | 16 | 8 | 1 | 1 | >128 | 128 | 32 | <0.125 | 0.25 | <0.125 |
| Polymyxin B | 1 | 1 | 1 | 32 | >32 | 4 | 1 | 0.5 | 1 | 128 | 8 | 16 | 1 | <0.125 | 128 | >32 | 16 | 0.5 | 0.25 | 0.5 |
| FADDI-019 | 4 | 4 | 8 | 4 | 2 | 8 | 1 | 4 | / | 32 | 16 | 8 | 4 | 4 | >32 | 32 | 16 | 2 | 1 | 1 |
| FADDI-020 | 2 | 4 | 4 | 2 | 2 | 8 | 4 | 2 | / | 32 | 4 | 4 | 4 | 2 | >32 | >32 | 8 | 4 | 4 | 2 |
| FADDI-043 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 8 | 4 | 4 | 8 | 4 | 8 | 16 | / | / | / | / | / | / |
| FADDI-053 | 2 | 2 | 2 | >32 | / | 16 | 4 | 2 | 1 | >32 | 32 | 8 | 2 | / | / | / | / | / | / | / |
| FADDI-063 | 1 | / | / | >32 | / | / | 1 | / | / | >32 | 2 | / | 16 | / | / | / | / | / | / | / |
| FADDI-065 | 2 | 2 | 8 | >32 | >32 | 32 | 2 | 1 | / | >32 | 32 | 32 | 0.25 | 0.5 | >32 | >32 | >32 | 1 | 0.5 | 0.5 |
| FADDI-167 | 2 | 2 | 32 | >32 | >32 | >32 | 16 | 16 | / | >32 | >32 | >32 | >32 | 1 | >32 | >32 | >32 | 8 | 1 | 2 |
| FADDI-168 | 2 | 4 | 14 | >32 | >32 | 4 | 4 | 8 | / | >32 | >32 | >32 | >32 | 0.5 | >32 | >32 | >32 | 0.5 | 0.5 | 0.5 |
| FADDI-169 | 2 | 4 | 16 | >32 | >32 | >32 | 16 | 32 | / | >32 | >32 | >32 | >32 | 1 | >32 | >32 | 8 | 8 | 1 | 2 |
| FADDI-170 | 2 | 4 | 32 | >32 | >32 | >32 | >32 | >32 | / | >32 | >32 | >32 | >32 | 4 | >32 | >32 | >32 | 8 | 8 | 8 |
| FADDI-171 | 2 | 4 | 8 | 8 | 8 | 8 | >32 | >32 | / | >32 | >32 | >32 | >32 | 8 | >32 | >32 | >32 | 8 | 16 | 8 |
| FADDI-172 | 4 | 4 | >32 | >32 | >32 | >32 | >32 | >32 | / | >32 | >32 | >32 | >32 | 4 | >32 | >32 | >32 | >32 | 8 | 16 |
| FADDI-175 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | / | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | 32 | 32 |
| FADDI-176 | >32 | 16 | >32 | >32 | >32 | >32 | >32 | >32 | / | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 |
| FADDI-177 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | / | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 |
| FADDI-180 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | / | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 |
| FADDI-187 | 1 | 2 | 2 | >32 | >32 | >32 | >32 | >32 | / | >32 | >32 | >32 | >32 | 4 | >32 | >32 | >32 | 16 | 26 | 8 |
| FADDI-206 | 1 | 1 | 4 | >32 | >32 | >32 | 1 | 1 | / | >32 | 8 | 2 | 2 | 0.25 | >32 | >32 | >32 | 0.5 | 0.25 | 0.25 |
| FADDI-207 | 1 | 2 | 4 | >32 | >32 | >32 | 8 | 8 | / | >32 | >32 | 16 | 16 | 0.25 | >32 | >32 | >32 | 1 | 0.25 | 0.5 |
/=Not determined