Fig. 5a, b.

Infection of DCs by LCMV. a The comparison of the anatomic localization of viral nucleic acids in spleen between Cl 13 and ARM at day 3 after infection shows ARM nucleic acid localized predominantly in the red pulp (RP) and Cl 13 nucleic acid localized with the white pulp (WP) or its marginal zone (MZ). A higher-power view is shown of both panels. The arrows indicate viral nucleic detected in individual cells. b Replication of Cl 13 and ARM in DCs in vivo over a 20-day observation period. Four adult BALB/c ByJ mice were infected with ARM or Cl 13. CD11c⁺ and DEC-205⁺ cells obtained from spleens made into single splenocyte suspensions were labeled with specific antibodies for these cell subsets. (■) CD11c⁺ DCs; (●) DEC-205⁺ DCs