Table 3.
Multivariate analysis of OS
| Group | Status | N | Hazard ratio (95 % CI) | P value |
|---|---|---|---|---|
| Arm | Surgery only | 414 | 1 | <0.0001 |
| S-1 | 412 | 0.593 (0.462–0.761) | ||
| Sex | Female | 263 | 1 | 0.740 |
| Male | 563 | 0.955 (0.729–1.251) | ||
| Age | <60 years | 318 | 1 | 0.0017 |
| 60–69 years | 310 | 1.301 (1.104–1.532) | ||
| 70–80 years | 198 | 1.693 (1.219–2.347) | ||
| Stage | II | 372 | 1 | <0.001 |
| IIIa | 318 | 1.649 (1.402–1.940) | ||
| IIIb | 136 | 2.719 (1.966–3.764) | ||
| Histology | Differentiated | 331 | 1 | 0.337 |
| Undifferentiateda | 495 | 1.135 (0.876–1.471) | ||
| AREG | Low | 413 | 1 | 0.001 |
| High | 413 | 0.658 (0.513–0.844) | ||
| IGF1R | Low | 412 | 1 | <0.0001 |
| High | 414 | 1.716 (1.332–2.212) |
aIncluding three patients with gastric cancer categorized as neither differentiated nor undifferentiated type