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. 2017 Feb 17;8:14487. doi: 10.1038/ncomms14487

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Copyright © 2017, The Author(s)

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Mice were injected with tamoxifen from P21 to 23 and ABR tests were performed 1, 4, 8 and 16 weeks later. (a) Averaged ABR traces of control and DTA(+/−):Plp1/Cre(+/−) mice at 11.3 kHz, 70 dB SPL. Five ABR peaks are labelled with I-V. Arrows indicate SP and ABR P1 AP. (b) The SP of DTA(+/−):Plp1/Cre(+/−) mice are not affected at all time points examined. (c) ABR P1 AP were reduced in DTA(+/−):Plp1/Cre(+/−) mice at all time points examined. (d) Ratios of SP/AP are increased in DTA(+/−):Plp1/Cre(+/−) mice 4, 8 and 16 weeks after tamoxifen induction. Tmx+1 week, n=17–21; Tmx+4 weeks, n=16–20; Tmx+8 weeks, n=10–14; Tmx+16 weeks, n=7–8 of each animal group. *P<0.05, **P<0.01 and ***P<0.001 by two-way ANOVA. Data are expressed as mean± s.e.m.