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. 2017 Feb 21;8:14294. doi: 10.1038/ncomms14294

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Copyright © 2017, The Author(s)

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(a) Representative microCT scans of tumours in Kras^LSLG12D/+; Trp53^flox/flox; Fosl1^+/+ (KP) and Kras^LSL-G12D/+; Trp53^flox/flox; Fosl1^flox/flox (KPF) mice treated with AdCre and allowed to develop tumours for 12 weeks. (b) Representative H and E stained sections of KP and KPF lungs. Scale bar is 6 mm. (c) Dot plot of the quantification of tumour area in KP (n=16) and KPF (n=16) groups (n, number of mice per group). Error bars correspond to s.e.m. P value obtained using a Mann–Whitney test. (d) Dot plot showing mean number of tumours per mouse in KP and KPF mice. Error bars correspond to s.e.m. P value obtained using Student's t-test. (e) Bar graph of the average of tumour size in KP and KPF groups. Error bars correspond to s.e.m. P values obtained using Student's t-test. (f) Kaplan–Meier plot of KP (n=20) and KPF (n=16) mice. P values obtained using the log-rank test (Mantel-Cox). *P<0.05; ***P<0.001.