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. 2017 Feb;18(1):75–92. doi: 10.2174/1389202917666160808125213

Fig. (2).

Fig. (2)

Proposed model for topoisomerase inhibitor mediated cellular death. Inhibition of DNA topoisomerases by catalytic topoisomerase inhibitors or topoisomerase poisons interferes with DNA replication, recombination, transcription and decatenation, and causes DNA damage. These generate cellular stress, lead to cell cycle arrest and ultimately induce apoptotic cell death pathway.