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. 2017 Feb 21;8:14575. doi: 10.1038/ncomms14575

Figure 7. TAM receptor expression is elevated in the placenta and induced by ZIKV infection.

Figure 7

Pregnant CD1 dams underwent a mini-laparotomy in the lower abdomen for intrauterine (IU) inoculation of ZIKV (1968 Nigeria) or mock infection at embryonic day 10. Maternal spleens and placentas were harvested 48 h post-inoculation, and TAM receptor expression was measured by qRT-PCR. Relative (a) Mertk, (b) Axl and (c) Gas6 expression was compared between the spleen and placenta of mock- and ZIKV-infected dams. For each panel, gene expression is presented relative to the housekeeping gene, Gapdh, with the median indicated by the solid line for each group For each panel, paired t-tests (spleen versus placenta) and Mann-Whitney (mock versus ZIKV) analyses, *=significant difference at P<0.05 between mock and ZIKV infections. †=significant difference at P<0.05 between expression levels in paired spleen and placentas within an infection group.