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. 2017 Jan 28;6(2):136–146. doi: 10.1002/psp4.12153

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© 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Pharmacodynamic (PD) response of individual genes. PD responses of significantly perturbed genes following drug administration of acetaminophen (APAP) as single toxic dose and correspondent PD effects induced by co‐administration of caffeine (CAF). Genes were classified according to their functional classes. Relative PD effect values indicated by percentages were only shown for highly regulated genes (absolute fold change>1.5 and absolute relative PD effect>10%). (a) Kinase/Phosphatase. (b) Cytokine/Growth factor. (c) Receptor. (d) Ion channel/Transporter. (e) Metabolic enzyme. (f) Transcription/Translation regulator.