Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Dose escalation study. Pharmacodynamic (PD) responses were predicted following single administration of acetaminophen (APAP; solid lines) and co‐administration of APAP and caffeine (CAF; dashed lines). The doses were stepwise increased from therapeutic (ther) to toxic (tox) dose levels. (a) Individual genes. (b) Key cellular processes.
