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Observed and simulated concentration‐time profiles of morphine with the adult physiologically based pharmacokinetic (PBPK) model. Open circles represent the observed data from reported clinical studies: Hoskin et al.18; Lötsch et al.23; Lötsch et al.24; Stuart‐Harris et al.25; Dershwitz et al.26; Säwe et al.17 Details on parameter settings used for each simulation in this study are summarized in Supplementary Table S1.
